Christophe Benoist is a molecular immunologist, currently the Morton Grove-Rasmussen Chair in Immunohematology at Harvard Medical School.
The Benoist/Mathis lab works in the fields of T cell tolerance and autoimmunity, attempting to decipher the molecular and cellular mechanisms that control T cell differentiation, the acquisition and maintenance of immunological tolerance or its failure in autoimmune diseases.
The lab has historically generated a number of important mouse models of tolerance and autoimmunity, made seminal contributions to the understanding of gene regulation in the immune system, the role of the Aire gene in immunological tolerance, the impact of T-regulatory cells in the control of immune and inflammatory responses. Current investigations use a broad range of “Systems Immunology” approaches to decipher immunoregulation in mice and humans, and the microbiome’s influence on these processes